Research Areas
Our lab connects human disease samples, immune-cell mechanisms, and engineered cellular therapies.
T Cell Engineering
Some of the strongest clues for better cell therapy are already written in T cells themselves.
We study naturally occurring mutations and elite immune-cell states to discover programs that can make engineered T cells more durable, tumor-directed, and resistant to exhaustion.
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Autoimmune Disease
Autoimmune diseases emerge when protective immune programs are redirected against the body’s own tissues.
Using patient samples, single-cell profiling, and functional studies, we uncover the T cell circuits that sustain inflammation and point toward strategies for restoring immune balance.
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T Cell Lymphoma
T cell lymphomas are rare, aggressive cancers driven by immune cells that have turned malignant.
We map their mutations, signaling dependencies, and survival programs to reveal what keeps these cancers alive — and where smarter therapies may be able to intervene.
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Precision Medicine
Every patient’s immune disease carries a unique molecular fingerprint.
We integrate patient samples, single-cell and spatial data, and functional testing to turn complex biology into clearer therapeutic hypotheses, biomarkers, and paths toward personalized care.
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